Figure 1

Bipartite network of genes and renal diseases. A bipartite network on the left (automatically generated by the Fruchterman-Rheingold algorithm [20]) showing the relationship between 7 renal diseases (white nodes), and 747 genes (black nodes). The size of the nodes is proportional to the edges that connect to them. Therefore diseases with many genes have large nodes, whereas diseases with few genes have smaller nodes. The light edges (orange colored) represent up-regulated genes, the dark edges (blue colored) represent down-regulated genes, and gene node labels are the numerical identifiers for each gene from the Entrez Gene database. The inset shows that the genes regulated by all four of the high degree diseases (SLE, FSGS, MGN, and IgAN) are mostly down-regulated (shown as having mostly dark edges), whereas those regulated by a subset of the diseases shown (SLE, MGN, and FSGS) are mostly up-regulated (shown as having mostly light edges).