Network analysis of genes regulated in renal diseases: implications for a molecular-based classification

BMC Bioinformatics

Table 1 Current classification for chronic renal diseases, and the number of patients in the experimental and control groups

Classification for chronic renal diseases	Exp.	Ctrl.
"Predominant" Inflammatory
IgA Nephropathy (IgAN)	25	6
Systemic lupus erythematosus (SLE)	32	15
"Predominant" Non-Inflammatory
Focal & segmental glomerulosclerosis (FSGS)	10	15
Membranous glomerulonephritis (MGN)	18	15
Minimal change disease (MCD)	4	3
Thin membrane disease (TMD)	6	3
"Predominant" Metabolic
Diabetic nephropathy (DN)	11	3
Total	106	60

The dataset consisted of biopsies from 106 patients diagnosed with one of 7 renal diseases, and compared with biopsies from 60 healthy patients within the same expression analysis batch. A test of significance between the two groups resulted in 747 genes implicated across the 7 chronic renal diseases.

ISSN: 1471-2105