Model of the potential role of Mef2c, Myogenin, and Creb family of TF in regulation of Sost and DMP1. Prostaglandins and Pth can activate the Creb family of TF and regulate DMP1. DMP1 also has several Mef2 site and three are close to 2 myogenin sites. Myogenin and Mef2 synergize in activating several muscle related genes and possibly DMP1. Sost gene 5 kb region may also be regulated by Mef2 TF and Myogenin in this 5 kb region.