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Table 2 Top 20 pathways identified using the proposed approach.

From: Detection of gene pathways with predictive power for breast cancer prognosis

Pathway

Size

P-value

Glutamate metabolism

5

2.22E-16

Amyotrophic lateral sclerosis (ALS)

6

5.55E-15

Colorectal cancer

19

2.26E-13

Small cell lung cancer

27

1.15E-12

Streptomycin biosynthesis

2

1.95E-12

Cell cycle

36

3.10E-12

Prion disease

4

3.37E-12

Renin-angiotensin system

2

8.99E-12

Nicotinate and nicotinamide metabolism

5

1.13E-11

Circadian rhythm

2

4.24E-11

Glycerophospholipid metabolism

14

4.36E-11

Prostate cancer

20

1.21E-10

Apoptosis

27

4.67E-10

Oxidative phosphorylation

15

7.32E-10

Synthesis and degradation of ketone bodies

2

8.75E-10

D-Glutamine and D-glutamate metabolism

2

1.78E-09

Focal adhesion

49

2.07E-09

Dentatorubropallidoluysian atrophy (DRPLA)

5

2.24E-09

Renal cell carcinoma

17

5.06E-09

Neurodegenerative Disorders

10

5.56E-09

  1. Size: number of genes in the pathway; p-value: unadjusted p-value.