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Table 8 Summary of the prediction results of the 10 most frequent mutations and their related drugs extracted from text compares with the HIVDB on two levels and three levels of resistance: susceptible (S), intermediate resistant (I), and resistant (R).

From: Extracting causal relations on HIV drug resistance from literature

Mutation Drugs Agreement with the Stanford HIVDB output (%)
   Two levels: S, R Three levels: S, I, R
I84V ATV, IDV, LPV, NFV, SQV, TPV 6/6 6/6
K103N AZT, DLV, EFV, NVP 3/4 6/6
K65R 3TC, ABC, AZT, D4T, DDI, FTC, TDF 7/7 7/7
L74V 3TC, ABC, AZT, D4T, DDI 3/5 3/5
L90M ATV, IDV, LPV, NFV, SQV 5/5 4/5
M184V 3TC, ABC, AZT, D4T, DDI, EFV, FTC, NVP, TDF 6/9 7/9
M46I ATV, IDV, NFV, SQV 3/4 2/4
Q151M 3TC, ABC, AZT, D4T, DDI 5/5 3/5
V82A IDV, LPV, NFV, SQV 4/4 3/4
Y181C AZT, D4T, DLV, EFV, NVP 4/5 3/5
Over all 85% 76%