Free energy estimation of short DNA duplex hybridizations

BMC Bioinformatics

Table 3 Summary of results for free energy measurements obtained with EVAL-FE methods.

Method	Statistics	MFE_AD [kcal/mol]	Pearson coeff. (r)	RMSE
MultiRNAFold	min	0.0000	0.7352	4.418
(Mathews)	q1	0.300
	median	0.800
	mean	2.672
	q3	3.395
	max	18.400
	stddev	3.521
MultiRNAFold	min	0.0000	0.7456	4.223
(SantaLucia)	q1	0.330
	median	0.680
	mean	2.553
	q3	3.390
	max	17.200
	stddev	3.367
	min	0.0000	0.7434	4.101
	q1	0.2528
	median	0.6128
UNAFold	mean	2.4110
	q3	2.9970
	max	13.0000
	stddev	3.319
Vienna	min	0.0000	0.7413	3.876
Package	q1	1.820
	median	2.440
	mean	3.167
	q3	3.965
	max	15.400
	stddev	2.236

Summary of results for free energy measurements obtained with EVAL-FE methods. The p-values for the Pearson correlation test were less than 2.2e-16 in all cases.

ISSN: 1471-2105