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Table 3 Summary of results for free energy measurements obtained with EVAL-FE methods.

From: Free energy estimation of short DNA duplex hybridizations

Method Statistics MFE_AD [kcal/mol] Pearson coeff. (r) RMSE
MultiRNAFold min 0.0000 0.7352 4.418
(Mathews) q1 0.300   
  median 0.800   
  mean 2.672   
  q3 3.395   
  max 18.400   
  stddev 3.521   
MultiRNAFold min 0.0000 0.7456 4.223
(SantaLucia) q1 0.330   
  median 0.680   
  mean 2.553   
  q3 3.390   
  max 17.200   
  stddev 3.367   
  min 0.0000 0.7434 4.101
  q1 0.2528   
  median 0.6128   
UNAFold mean 2.4110   
  q3 2.9970   
  max 13.0000   
  stddev 3.319   
Vienna min 0.0000 0.7413 3.876
Package q1 1.820   
  median 2.440   
  mean 3.167   
  q3 3.965   
  max 15.400   
  stddev 2.236   
  1. Summary of results for free energy measurements obtained with EVAL-FE methods. The p-values for the Pearson correlation test were less than 2.2e-16 in all cases.