Figure 1From: Statistical method on nonrandom clustering with application to somatic mutations in cancerRibbon representation of the PI3K α. Ribbon representation of the PI3Kα helical domain (blue) and kinase domain (magenta) extracted from the p110α/p85α complex (PDB Code: 2RD0; Berman et al. (2000) [45]; Huang et al. (2007) [46]). Displayed in CPK representations are sites of major oncogenic mutations: Pro539, Glu542, Glu545 and Gln546 in the helical domain (blue); Arg1023, Thr1025, His1047 and Gly1049 in the kinase domain (pink). The ATP binding site in the kinase domain is highlighted with a surface.Back to article page