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Figure 5 | BMC Bioinformatics

Figure 5

From: Mathematical model for empirically optimizing large scale production of soluble protein domains

Figure 5

Dependence of e domain on N. edomain and Noptimum were calculated for the multiple and single copy cases with, respectively, Eq. 6 (solid lines) and Eq. 7 (symbols). (a) edomain is represented as a function of N for p(S| D) = 1, 0.63, 0.3, and 0.1. The curve for the special case of f = 1 [p(S| D) = 0.0011] is shown in the inserted panel, with vertical scale magnified 300 times. (b) Curves for r > 0 and F = 16 and 900. edomain are shown for r = 0, 1, 5, 10, and 100 with p(S| D) = 0.63. Noptimum > 1 is clearly apparent. (c) Noptimum is shown as a function of p(S| D) for r = 1, 10, 100, and 1,000. Noptimum can be any positive number. Noptimum for the single copy case are discrete in N (symbols), while those for the multiple copy case are continuous (dotted lines). Discretization of the single copy model (solid lines) caused a small discrepancy at the very edge of switching a step of solutions.

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