TY - JOUR AU - Guerra-Assunção, José Afonso AU - Enright, Anton J. PY - 2010 DA - 2010/03/16 TI - MapMi: automated mapping of microRNA loci JO - BMC Bioinformatics SP - 133 VL - 11 IS - 1 AB - A large effort to discover microRNAs (miRNAs) has been under way. Currently miRBase is their primary repository, providing annotations of primary sequences, precursors and probable genomic loci. In many cases miRNAs are identical or very similar between related (or in some cases more distant) species. However, miRBase focuses on those species for which miRNAs have been directly confirmed. Secondly, specific miRNAs or their loci are sometimes not annotated even in well-covered species. We sought to address this problem by developing a computational system for automated mapping of miRNAs within and across species. Given the sequence of a known miRNA in one species it is relatively straightforward to determine likely loci of that miRNA in other species. Our primary goal is not the discovery of novel miRNAs but the mapping of validated miRNAs in one species to their most likely orthologues in other species. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-11-133 DO - 10.1186/1471-2105-11-133 ID - Guerra-Assunção2010 ER -