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Table 2 Cumulative binomial and binomial p-values for motif example described in Methods

From: Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins

Motif (k)

p μ

B(k, N, p 1 + motif )

k

0

1

2

3

4

0

1

2

3

4

LL(4)

1

1

1

1

0.9948

0

0

0.0001

0.005

0.9948

WW(1)

1

0.1485

0.0088

0.0002

0

0.8515

0.1397

0.0086

0.0002

0

WL(1)

1

0.7789

0.3736

0.0949

0.0098

0.2211

0.4053

0.2787

0.0852

0.00948

LW(1)

1

0.7789

0.3736

0.0949

0.0098

0.2211

0.4053

0.2787

0.0852

0.00948

  1. Incomplete beta and binomial shows the cumulative binomial and binomial p-values respectively for each motif for all supports between 0 and N = 4. p1+μis the success probability of the motif considered. The value in italics indicates the highest scoring motif in the example described. The bold values indicate the values of k for which I(k, N, pm) < = 0.1485, the p μ value of the highest ranking motif. The five right hand columns are only shown to illustrate how the probabilities in the left hand columns are calculated (with sums across the bold values in the right hand columns cells totaling the values in the left hand columns).