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Figure 6 | BMC Bioinformatics

Figure 6

From: Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity

Figure 6

A conformational transformation candidate, as modeled by structural matching. Enolase (PDB [59] identifier 1pdy; white) and signal recognition 54 kda protein (1j8yF; N-terminal red, C-terminal blue). Hypothetical use of enolase as the scaffolding to model conformational change in the signal recognition particle. (A) Applying the linear coordinate transformation which overlaps the larger (C-terminal) domain of the two proteins to both domains in the signal recognition particle. (B) Transforming both the larger and the smaller domain separately to obtain the maximal overlap with enolase structure. (C) The model for conformational change in the signal recognition particle, based on (A) and (B). Note that the structural match in itself does not in itself imply functional relatedness nor common evolutionary descent.

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