Table 2 Enriched pathways in the top 500 probe sets ranked by Notch pathway-guided COCA approach
From: Knowledge-guided gene ranking by coordinative component analysis
Pathway Term | Count | % | p-value | FDR |
|---|---|---|---|---|
Pentose and glucuronate interconversions | 8 | 1.70% | 1.64E-06 | 0.00001847 |
Notch signaling pathway | 8 | 1.70% | 5.65E-04 | 0.00640122 |
Porphyrin and chlorophyll metabolism | 7 | 1.49% | 6.28E-04 | 0.00719142 |
p53 signaling pathway | 9 | 1.91% | 9.87E-04 | 0.01107482 |
Cell cycle | 11 | 2.34% | 0.002362 | 0.02596788 |
Starch and sucrose metabolism | 8 | 1.70% | 0.002805 | 0.03161464 |
Androgen and estrogen metabolism | 7 | 1.49% | 0.002846 | 0.03237976 |
Polyunsaturated fatty acid biosynthesis | 4 | 0.85% | 0.015829 | 0.1738869 |
Metabolism of xenobiotics by cytochrome P450 | 7 | 1.49% | 0.022415 | 0.2321759 |
Glycolysis/Gluconeogenesis | 6 | 1.28% | 0.024584 | 0.253719 |
Fructose and mannose metabolism | 5 | 1.06% | 0.054919 | 0.4893802 |
Galactose metabolism | 4 | 0.85% | 0.075736 | 0.6119058 |
PPAR signaling pathway | 6 | 1.28% | 0.083934 | 0.6456008 |