New components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data

BMC Bioinformatics

Table 1 Retrospective analysis of high-ranking genes

Bayesian Rank	Co-exp Rank	Gene name	Mutant phenotype^a	Reference
4	16	dhkK	Aberrant slug migration	[40]
33	31	gbfA	Development arrests at mound stage	[41]
42	69	wimA	Aberrant fruiting body morphology	[42]
77	44	dhkC	Precocious development	[43]
79	8	comC	Aberrant aggregation	[44]
92	174	rzpA	Aberrant aggregation	[45]
112	NA	egeB	Development arrests at mound stage	[37]
115	NA	Sel1-like	Wild Type	[42]
118	138	DG1037	No aggregation	[42]
122	208	mybE	Increased slug size	[46]
123	157	CRTF	No aggregation	[47]
140	178	cudA	Development arrests at slug stage	[48]
189	214	tsg101	Small fruiting body	[49]
204	NA	cbpC	Delayed culmination	[50]

NA - Not ranked in the top 5% of the distribution; a - Mutant phenotypes were obtained from http://dictybase.org/. Twelve of the 13 high-ranking genes with published mutant phenotypes exhibit developmentally abnormal phenotypes when mutated.

ISSN: 1471-2105