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Table 1 Significant GO nodes

From: Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections

Significant GO Nodes at 24 Hours

GO ID

GO description

p -value

gene

gene description

log 2 (avg. fold change)

6955

Immune response

p = 6.23 × 10-16

   AIM2

absent in melanoma 2

2.71

   CCL5

chemokine (C-C motif) ligand 5

1.64

   CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

1.53

   EDG6

endothelial differentiation, lysophosphatidic acid GPCR 6

-1.22

   EXO1

exonuclease 1

0.08

   GBP1

guanylate binding protein 1, interferon-inducible, 67 kDa

1.75

   GBP4

guanylate binding protein 4

1.25

   OAS1

2',5'-oligoadenylate synthetase 1, 40/46 kDa

1.91

   OAS2

2',5'-oligoadenylate synthetase 2, 69/71 kDa

2.36

   OAS3

2',5'-oligoadenylate synthetase 3, 100 kDa

2.68

   SPON2

spondin 2, extracellular matrix protein

-1.29

   TAP1

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

1.63

7049

Cell Cycle

p = 1.88 × 10-10

   CCNA2

cyclin A2

1.58

   CCNE2

cyclin E2

2.32

   CDC6

CDC6 cell division cycle 6 homolog (S. cerevisiae)

1.86

   E2F1

E2F transcriptoin factor 1

1.37

   MCM6

MCM6 minichromosome maintenance deficient 6

2.05

   PRC1

protein regulator of cytokinesis 1

1.17

   SPC25

kinetochore protein

2.15

   TXNIP

thioredoxin interacting protein

1.29

   UHRF1

ubiquitin-like, containing PHD and RING finger domains, 1

1.63

9615

Response to Virus

p = 5.98 × 10-9

   CCL5

chemokine (C-C motif) ligand 5

1.64

   IFIH1

interferon induced with helicase C domain 1

1.87

   IRF7

interferon regulatory factor 7

1.76

   MX1

myxovirus (influenza virus) resistance 1, interferon-inducible prot. p78 (mouse)

2.57

   MX2

myxovirus (influenza virus) resistance 2 (mouse)

2.43

   OAS1

2',5'-oligoadenylate synthetase 1, 40/46 kDa

1.91

   STAT1

signal transducer and activator of transcription 1, 91 kDa

1.66

6260

DNA Replication

p = 8.92 × 10-9

   MCM6

MCM6 minichromosome maintenance deficient 6

2.05

   MCM10

MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)

2.10

  1. The most significant GO nodes are given with their raw p-values. Under each GO entry is a list of the genes associated with that node.
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BMC Bioinformatics

ISSN: 1471-2105

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