Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections

Table 4 Genes common to significance and SVM analyses

SVM Gene	log₂(Fold Change)	Description (if available)	8 hrs	24 hrs
CYR61	-1.51	cysteine-rich, angiogenic inducer, 61	+	+
SOCS3	-1.06	suppressor of cytokine signaling 3	-	+
AK024238	-1.32	mRNA, possibly cadherin 6, type 2 (CDH6)	+	+
AA768672	-1.47	mRNA, possibly LSM14A	+	+
THC2348879	-1.22		+	-
THC2313287	-2.74		+	+
IER2	-1.64	immediate early response 2	+	+
ZFP36	-1.74	zinc finger protein 36	+	+
FOS	-3.47	v-fos FBJ murine osteosarcoma viral oncogene homolog	+	+
NFKBIE	1.08	nuclear factor of kapppa light polypeptide gene enhancer in B-cells inhibitor	+	+
AT_nC_3	-1.32		+	-
CTGF	-1.43	connective tissue growth factor	+	-
AF159295	-1.89	mRNA, MAP/microtubule affinity-regulating kinase 3 (MARK3)	+	+
JUN	-1.74	v-jun sarcoma virus 17 oncogene homolog (avian)	+	+
FOSB	-2.18	FBJ murien osteosarcoma viral oncogene homolog B	+	+
EGR1	-3.18	early growth response 1	+	+
HP1BP3	-1.00	heterochromatin protein 1, binding protein 3	+	-
DUSP1	-1.79	dual specificity phosphatase 1	+	+
ABCC3	1.38	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	+	+
FOXC1	-1.15	forkhead box C1	-	+
SFRS5	-1.47	splicing factor, arginine/serine-rich 5	+	+
DB363693	-1.43		+	-
THC2343678	-1.47		+	+
A_24_P161068	-1.09		-	+

Genes are listed in order of importance in the SVM analysis. The fold change in each gene is the average fold change in gene expression including both the 8 and 24 hour data. In the last two columns, a "+" indicates that the gene was found in both the Significance and SVM Analyses at 8 or 24 hours, respectively. A "-" indicates that the gene was not found in the results in both analyses at 8 or 24 hours. Genes through sfrs5 are among the top 35 and through the end of the list are in the top 43.

ISSN: 1471-2105