Figure 5
From: Optimization algorithms for functional deimmunization of therapeutic proteins
Full-length SakSTAR variant profile. Optimized 6-substitution full-length SakSTAR variant with ProPred epitope scoring and conservation-based substitutions. x-axis: starting position of each 9-mer; y-axis: predicted number of alleles recognizing the 9-mer. Thin black bars indicate wild-type scores and thick orange bars indicate variant scores. Note: wild-type epitope scores are always greater than or equal to corresponding variant ones; i.e., we never introduce new epitopes. Blue ellipses indicate mutated positions (refer to Table 2).