Skip to main content
Figure 6 | BMC Bioinformatics

Figure 6

From: Optimization algorithms for functional deimmunization of therapeutic proteins

Figure 6

SakSTAR peptide with ProPred 5% and 10% thresholds. Optimized SakSTAR peptide variant with ProPred epitope scoring at 5% (top) and 10% (bottom) thresholds. x-axis: starting position of each 9-mer; y-axis: predicted number of alleles recognizing the 9-mer. Thin black bars indicate wild-type scores and thick orange bars indicate variant scores. Note: wild-type epitope scores are always greater than or equal to corresponding variant ones; i.e., we never introduce new epitopes. The blue ellipse indicates BLOSUM-based substitution V79T.

Back to article page