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Table 2 Feature weights for siRNA design derived from multi-task learning

From: Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study

No. Feature Weight
1 position-dependent nucleotide consensus: sum 0.1954
2 Δ G difference between positions 1 and 18 0.0987
3 Δ G of sense-antisense siRNA duplexes 0.0774
4 position-dependent nucleotide consensus: preferred 0.0733
5 preferred dinucleotide content index 0.0726
6 local target mRNA stabilities (Δ G) 0.0651
7 position-dependent nucleotide consensus: avoided 0.0640
8 nucleotide content: U 0.0603
9 stability (Δ G) of dimers of siRNAs antisense strands 0.0537
10 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 1 0.0384
11 siRNA antisense strand intra-molecular structure stability (Δ G) 0.0327
12 avoid dinucleotide content index 0.0324
13 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 13 0.0298
14 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 18 0.0279
15 nucleotide content: G 0.0267
16 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 2 0.0222
17 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 6 0.0159
18 stability profile for each two neighboring base pairs in the siRNA sense-antisense in position 14 0.0138
19 frequency of potential targets for siRNA 0.0000