Figure 6
From: Systematic calibration of a cell signaling network model
Quantitative model calibration by multi-start method. (a) Plot showing the multiple optimal solutions obtained by deterministic multi-start global optimization and sorted according to the magnitude of the objective function. (b, c) Plot comparing the simulated time course of PARP cleavage (lines) to single-cell data (diamond, triangle and circle markers) for cells treated with 250 ng/mL (blue), 50 ng/mL (red), or 10 ng/mL (green) TRAIL. Models simulations were derived from a local optimum (b) or a global optimum (c) of the deterministic multi-start global optimization.