Table 1 The computational methods used for analyzing the network model
From: Systematic calibration of a cell signaling network model
| Â | Computational methods | Searching principle | Reference |
|---|---|---|---|
Sensitivity analysis | Local sensitivity | Local | Â |
| Â | Average of local sensitivities | Global | [17] |
| Â | Sobol's method | Â | [11] |
|  |    First-order sensitivity | Global |  |
|  |    Total-effect sensitivity | Global |  |
Parameter estimation | Local estimation | Local, deterministic | Â |
| Â | Multi-start of local estimations | Global, deterministic | Â |
| Â | Evolutionary strategy using stochastic ranking (SRES) | Global, stochastic | [22] |