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Table 1 The computational methods used for analyzing the network model

From: Systematic calibration of a cell signaling network model

  Computational methods Searching principle Reference
Sensitivity analysis Local sensitivity Local  
  Average of local sensitivities Global [17]
  Sobol's method   [11]
     First-order sensitivity Global  
     Total-effect sensitivity Global  
Parameter estimation Local estimation Local, deterministic  
  Multi-start of local estimations Global, deterministic  
  Evolutionary strategy using stochastic ranking (SRES) Global, stochastic [22]