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Table 2 Comparison of results from different global sensitivity indices

From: Systematic calibration of a cell signaling network model

 

Average of local sensitivities

Sobol's first order sensitivity

Sobol's total effect sensitivity

8 dominant parameters*

k8, k9, k 5 , kc1, k3, k 1 , k-_1, k4

kc1, k 12 , k3, k 13 , k9, k24, k 10 , k-1

kc1, k3, k 12 , k9, k 13 , k 1 , k 10 , k 5

CPU time

24 hours

160 hours

160 hours

Objective function

3.546

8.364

7.745

  1. * The common parameters identified by all the sensitivity indices were highlighted in bold style and the parameters by any of two different sensitivity indices were underlined.
  2. † Global optimization (Evolutionary Strategy using Stochastic Ranking) was executed with respect to the parameter combination selected by each sensitivity index.