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Table 2 Comparison of results from different global sensitivity indices

From: Systematic calibration of a cell signaling network model

  Average of local sensitivities Sobol's first order sensitivity Sobol's total effect sensitivity
8 dominant parameters* k8, k9, k 5 , kc1, k3, k 1 , k-_1, k4 kc1, k 12 , k3, k 13 , k9, k24, k 10 , k-1 kc1, k3, k 12 , k9, k 13 , k 1 , k 10 , k 5
CPU time 24 hours 160 hours 160 hours
Objective function 3.546 8.364 7.745
  1. * The common parameters identified by all the sensitivity indices were highlighted in bold style and the parameters by any of two different sensitivity indices were underlined.
  2. † Global optimization (Evolutionary Strategy using Stochastic Ranking) was executed with respect to the parameter combination selected by each sensitivity index.