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Table 2 EFGR diffusion-reaction model.

From: Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes

Description

Mechanism

Rate Constant

Diffusion:

  

central domain (M)

M1+ *1 → *1+ M1

2.50 105 s-1

outer domain (M)

M2+ *2 → *2+ M2

2.50 105 s-1

central domain (D)

D1+ *1 → *1+ D1

1.25 105 s-1

outer domain (D)

D2+ *2 → *2+ D2

1.25 105 s-1

Barrier (M)

M1+ *2 ↔ *1+ M2

2.50 102 s-1

Barrier (D)

D1+ *2 ↔ *1+ D2

1.25 10-1 s-1

Reactions:

  

Monomerization

D + * → M + M

1.70 10-2 s-1

Dimerization

M + M → D + *

5.67 102 s-1

  1. Notation: EGF receptor monomer (M), dimer (D), lattice vacancy (*), central domain (X1), outer domain (X2). Dimers occupy a single lattice site. Monomerization and dimerization reactions do not occur over a barrier.
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BMC Bioinformatics

ISSN: 1471-2105

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