Figure 6

Comparison with an existing modeling study. A Phase planes visualizing the attractor landscape of the Odefy-converted AND version of the mutual inhibitory switch from various initial conditions. We set the Hill parameter n to 2 in order to represent dimer binding of transription factors as proposed in the study by Roeder et al [23]. The self-activation threshold k _s was set to 0.01, resembling a highly sensitive self-activation in comparison to the mutual inhibition. B Simulation of the ODE system from [23] with a high unspecific transription rate. We show an exact reproduction of the phase plane displayed in Figure 2(h) from the original publication. Both dynamical systems are similar in terms of multistability, steady state positions and attractor basins, i.e. the initial values that fall into a certain steady state.