DCIM analysis of the top 500 DCS signature in the combined dataset. A) Expression patterns are consistent with the results for the individual datasets. B) ER status, tumor grade, and the expression levels of the ERα transcription factor. DCIM sample groupings are highly correlated with all three variables. C) LRpath analysis of enrichment by the genes up- and down-regulated by E2 and oncogenic pathways genes for the whole DCE signature. D) Separate LRpath analysis of enrichment for seven distinct sub-clusters. Gene expression profiles and functional annotations can be accessed and examined interactively at the support website http://eh3.uc.edu/gimm/dcim.