Figure 1

Comparison of Alignment Accuracy in Terms of Contact Overlap, TM-score, and Sequence similarity. Comparison of alignment accuracy measured in contact overlap, TM-score, and sequence similarity for SABERTOOTH (red), Clustal W (green), T-Coffee (brown), MUSCLE (magenta), PSI-BLAST on BLOSUM62 (blue), and HHpred (cyan). The black curves mark the 'best of' set. All alignments are sorted by increasing contact overlap of the 'best of' set from left to right. The abscissa is the resulting alignment number and the ordinates indicate the respective similarity measure with a running average of window size 100 applied to improve readability. SABERTOOTH structure alignment (orange) is added for illustrative purposes, but it is not included in the comparison. The SCOP level labels shown do not represent sharp borders, since the real assignments can overlap in this depiction.