Figure 2

Comparison of Significance Scores' Compliance with SCOP. ROC plots for prediction of SCOP fold, superfamily and family relationships using the significance scores output by different programs. In the left panels the ROC plots are shown in standard linear scale, in the right panels the ROC plot are shown in log-linear scale in order to better appreciate the behaviour at low false positive rate. The colour code is as follows: SABERTOOTH (red), the thick line refers to the r_PSSM,B62 based Z-score, while the thin line is relative to the seqSim_B62 based Z-score, Clustal W (green), T-Coffee (brown), PSI-BLAST on BLOSUM62 (blue), and HHpred (cyan). SABERTOOTH structure alignment (orange) is added for illustrative purposes, but it is not included in the comparison.