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Table 3 Inhibition parameters for independent sequence combinations of NNN that contain only purines or pyrimidines.

From: Antisense DNA parameters derived from next-nearest-neighbor analysis of experimental data

Parameters P (%) for five purine-containing independent sequences

Parameters P (%) for five pyrimidine-containing independent sequences

(A)12

35.7 ± 24.9

(UCC)4

44.2 ± 14.0

(AAG)4

29.1 ± 16.1

(U)12

9.7 ± 31.1

(G)12

24.8 ± 15.4

(UC)6

-19.4 ± 19.8

(AGG)4

22.4 ± 8.6

(UUC)4

-36.1 ± 14.9

(AG)6

6.2 ± 12.6

(C)12

-44.8 ± 24.7

  1. Inhibition parameters, P, from Table 2 for the five independent sequence combinations that contain only purines and the five that contain only pyrimidines. The former are generally more favorable target sequence combinations than those containing only pyrimidines.
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BMC Bioinformatics

ISSN: 1471-2105

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