Antisense DNA parameters derived from next-nearest-neighbor analysis of experimental data

BMC Bioinformatics

Table 5 Fits of data sets with NNN or NN parameters.

		Fit with in vivo NNN parameters		Fit with in vivo NN parameters		Fit with in vitro NN parameters
Experimental data	No. of Oligos	r _NNN	P _sig	r _NN	P _sig (NN)	r _NN	P _sig
CRAF1 (A549 cells)	26	0.636	<0.001	0.146	0.474	0.242	0.234
CRAF1 (T24 cells)	26	0.748	<0.001	0.493	0.010	0.403	0.041
BCL2 (A549 cells)	29	0.635	<0.001	0.148	0.441	0.231	0.229
PKC-α (T24 cells)	24	0.903	<0.001	0.130	0.544	0.639	<0.001
Published data PKC-α (A549 cells) [17]	20	0.561	0.010	0.716	<0.001	0.368	0.110

Correlation coefficients, r, and the significance of correlation, P_sig, between the indicated data sets and in vivo next-nearest-neighbor (NNN) parameters or in vivo or in vitro nearest-neighbor (NN) parameters. P_sig is the significance of the correlation coefficient by the t-test and is the probability of being wrong in rejecting the null hypothesis. The smaller the value of P_sig, the more significant the correlation.

ISSN: 1471-2105