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Table 5 Annotations of highly interconnected PPI subnetworks in malaria.

From: Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PFP

Centroid

Proteins (Edges)

Previous annotations (GO)

P-value a)

New annotations with PFP (GO)

P-value

Q8I1Q4

20 (24)

chromatin assembly or disassembly (0006333)

0.043

Myosin I binding (0017024)

0.004

  

chromosome organization and biogenesis sensu Eukaryota (0007001)

0.048

Cytoskeleton-dependent intracellular transport (0030705)

0.028

    

Structural constituent of nuclear pore (0017056)

0.020

    

mitotic cell cycle (0000278)

0.040

    

Nuclear export (0051168)

0.031

    

Nuclear import (0051170)

0.043

Q8I206

15 (16)

---

---

Nucleic acid transport (0050567)

0.003

    

Nucleobase, nucleoside, nucleotide and nucleic acid transport (0015931)

0.004

    

Transport (0006810)

0.045

    

Localization (0051179)

0.026

    

Regulation of gluconeogenesis (0006111)

0.017

    

Glucosyltransferase activity (0046527)

0.032

Q8I255

21 (21)

Signal transducer activity (0004871)

0.002

Hydrolase activity (0016787)

0.023

  

Receptor binding (0005102)

0.014

Translation regulator activity (0045182)

0.003

  

Pathogenesis (0009405)

0.009

Autotransporter activity (0015474)

0.041

  

Extracellular region (0005576)

0.022

Structural constituent of nuclear pore (0017056)

0.023

    

Localization (0051179)

0.008

    

Negative regulation of lymphocyte activation (0051250)

0.026

    

Peroxisome degradation (0030242)

0.023

    

Microtubule cytoskeleton organization and biogenesis (0000226)

0.008

    

Protein catabolism (0030163)

0.046

    

Intermediate filament cytoskeleton (0045111)

0.040

Q8I562

25 (31)

Cellular protein metabolism (0044267)

0.028

Cell death (0008219)

0.030

  

Protein folding (0006457)

0.022

RNA localization (0006403)

0.006

    

Anterior/posterior axis specification (0009948)

0.025

    

Anterior/posterior pattern formation (0009952)

0.025

    

Cytoskeleton organization and biogenesis (0007010)

0.027

    

Myosin II (0016460)

0.010

    

Actin cytoskeleton (0015629)

0.012

Q8I5X5

18 (27)

Transferase activity (0016740)

0.017

ATP binding (0005524)

0.0001

  

Glycolysis (0006096)

0.003

Cellular protein metabolism (0044267)

0.020

  

Macromolecule catabolism (0009057)

0.002

Catalytic activity (0003824)

0.047

  

Kinase activity (0016301)

0.036

Intermediate filament cytoskeleton (0045111)

0.030

    

Cytoskeleton-dependent intracellular transport (0030705)

0.002

Q8IKV2

18 (22)

Chromatin binding (0003682)

0.011

Adenyl nucleotide binding (0030554)

0.019

  

Chromatin assembly or disassembly (0006333)

0.043

Transcription coactivator activity (0003713)

0.007

  

Chromosome organization and biogenesis sensu Eukaryota (0007001)

0.048

RNA-mediated posttranscriptional gene silencing (0035194)

0.018

    

Translation regulator activity (0045182)

0.008

  1. a) The P-value is computed by Eqn. 15.