Figure 6

Schematic depiction for the detection of regions-of-interest. Schematic depiction for the detection of regions-of-interest, based on probe-intensities. Eight probes, with their genomic location, are shown in Panel A. Four of these have positive probe-intensities. The use of multiple thresholds, transforms continuous data into discrete data; as shown in Panel B and E. Various window scales N, are used to examine neighboring probes for their probe-intensities in Panel C and F. These windows will contain different number of positive probes. The hypergeometric probability is computed for every region-of-interest, and excludes a region-of-interest when the region is not statistically significant after correcting for a single positive probe in a region-of-interest and multiple testing. The remaining regions are merged for each k(t) (illustrated in Panel D, G, H) and then among all k(t) to a single region-of-interest (Panel I). To determine how often probes were detected in statistically significant regions, the probe-significance is computed (Panel D and E), and indicated with a red colored line that signifies the statistically significant probes in the detected region-of-interest.