HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data

BMC Bioinformatics

Table 2 HAT: Motif enrichment analysis using α = 0.05.

Nr	Motif	Hits	Fold Change	p-value
1	M00117.CEBPbeta	3236	2.082	6.187E-304
2	M00770.CEBP	6688	1.628	8.947E-299
3	M00912.C-EBP	6609	1.583	6.697E-265
4	M00116.CEBPalpha	5858	1.591	1.121E-239
5	cEBP	4068	1.758	1.875E-238
6	M00190.CEBP	5245	1.592	2.814E-215
7	M00716.ZF5	3927	1.706	2.121E-208
8	M00109.CEBPbeta	2645	1.896	3.059E-195
9	M00098.Pax-2	4355	1.619	1.761E-191
10	M00428.E2F-1	4374	1.572	4.665E-171

The top 10 motifs enriched in the 1910 detected regions-of-interest using HAT (α = 0.05) in the cebpa-study. There is a high enrichment for binding motif CEBP. For each reported motif, the number of hits within the regions-of-interest are counted, their fold change computed, and the p-value derived using the binomial test.

ISSN: 1471-2105