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Table 1 Summary of 14 semantic similarity scores for protein pairs.

From: Revealing and avoiding bias in semantic similarity scores for protein pairs

Measure

Description

Range

Similarity scores for term pairs

Resnik [6]

Information content of the most informative common ancestor of two terms

≥ 0

Lin [5]

Normalized Resnik similarity score by assessing how close two terms are to their most informative common ancestor

[0, 1)

RS [4]

Weighted Lin similarity score by using the probability of annotations of the most informative common ancestor

[0,1)

Jiang [7]

Based on the difference between two terms and their most informative common ancestor in information content

(0,1]

Similarity scores for protein pairs based on pairwise similarity scores between term groups

AVG [2]

The average of the similarity scores for all pairs of terms between two groups of protein annotations

Same with those for the corresponding similarity scores for term pairs

BMA [3]

The score of the best-matching pairs between two groups of protein annotations

 

Similarity scores for protein pairs based on groupwise similarity scores between term groups

TO [9]

The number of terms shared by the annotations for two proteins

≥ 1

NTO [9]

Dividing TO by the minimum of the annotation lengths of two proteins

(0,1]

Dice [12]

Dividing TO by the average of annotation lengths of two proteins

(0,1]

Kappa [11]

A chance-corrected measure of co-occurrence between two groups of protein annotations

[0, 1]

GIC [8]

Jaccard index weighted by the information content of each GO term

[0, 1]

VSM [10]

Cosine similarity weighted by the information content of each GO term

[0, 1]