Table 3 Success rates of different scoring functions on subsets of different types of molecular interactions
From: An interaction-motif-based scoring function for protein-ligand docking
Scoring function | Success rate (%) | |||
|---|---|---|---|---|
Overall (100) | Hydrophilic (44) | Mixed (32) | Hydrophobic (24) | |
MotifScore | 84 | 91 | 91 | 63 |
Cerius2/PLP | 76 | 77 | 78 | 71 |
SYBYL/F-Score | 74 | 75 | 75 | 71 |
Cerius2/LigScore | 74 | 77 | 75 | 67 |
DrugScorePDB | 72 | 73 | 81 | 58 |
Cerius2/LUDI | 67 | 75 | 66 | 54 |
X-Score | 66 | 82 | 59 | 46 |
AutoDock | 62 | 73 | 53 | 54 |
Cerius2/PMF | 52 | 68 | 44 | 33 |
SYBYL/G-Score | 42 | 55 | 34 | 29 |
SYBYL/ChemScore | 35 | 32 | 34 | 42 |
SYBYL/D-Score | 26 | 23 | 28 | 29 |