Figure 1
From: Prediction of epigenetically regulated genes in breast cancer cell lines
Computational pipeline. The computational pipeline for identification of epigenetically regulated genes from a panel of breast cancer cell lines. It was developed with the aim of (i) reducing the dimensionality of the methylation data, comprised of two sub-steps: (i.i) clustering of methylation profiles on the basis of proximity, and (i.ii) clustering within methylation sub-regions on the basis of similarity; (ii) associating the reduced methylation data to gene expression data; and (iii) ranking the methylation-expression associations according to their epigenetic regulation