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Figure 2 | BMC Bioinformatics

Figure 2

From: Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

Figure 2

The target gene regulatory network, NF-κB/RelA:P50. The most common NF-κB in the canonical NF-κB signaling pathway is a heterodimer that is composed of RelA and P50. RelA and P50 also can form homodimers and regulate gene expression. The regulatory relationships of NF-κB/RelA:P50 were obtained from the TRANFAC database and the MetaCore™ analytical suite, which both are knowledge bases, and the data were collected from manually curated peer-reviewed literature. Based on these databases, we filtered out some target genes of NF-κB/RelA:P50 that expressed insignificantly in the LPS-induced gene profiles. The regulatory network of NF-κB/RelA:P50 finally consisted of 54 total target genes with 77 transcription regulatory interactions.

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BMC Bioinformatics

ISSN: 1471-2105

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