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Figure 3 | BMC Bioinformatics

Figure 3

From: Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

Figure 3

The activity profiles of NF-κB reconstructed by NCA. These profiles represent the dose-dependent NF-κB activity with relative activation strengths that were reconstructed by reverse engineering modeling framework (NCA) using gene expression data among three different doses of LPS stimuli. Each profile contains data points at 0, 0.5, 2, 4, 6, and 12 hours. (A) The activity profile of NF-κB with 0.01 μg/ml LPS. This profile has only one peak at 2 hours and then decreases, but the activity decreases more slowly after four hours. (B) The activity profile of NF-κB with 0.1 μg/ml LPS. This profile has only one peak at 2 hours and then decreases, but the activity decreases more slowly after four hours. (C) The activity profile of NF-κB with 1 μg/ml LPS. This profile peaks at 2 hours but has a period of sustained (non-decreasing) activity between 4 hours and 6 hours.

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BMC Bioinformatics

ISSN: 1471-2105

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