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Figure 5 | BMC Bioinformatics

Figure 5

From: Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

Figure 5

Linking the NF-κB signaling pathway and gene responses by mapping the pattern of NF-κB profiles. By simulating the NF-κB signaling pathway, one of the NF-κB profiles (pink data points) that is induced by a specified IKK profile (green line) matches the pattern of the NF-κB profile (purple line) reconstructed from the gene expression data produced by NCA among the three different doses of LPS stimulus. In each conditions of LPS stimulus strength, the pattern of the two NF-κB profiles can be mapped at the time points of 0, 0.5, 2, 4, 6, and 12 hours with a Pearson correlation of ~0.99.

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BMC Bioinformatics

ISSN: 1471-2105

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