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Figure 7 | BMC Bioinformatics

Figure 7

From: Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

Figure 7

The influence strength and the critical cytokines and chemokines. (A) The top 20 influence strengths between the NF-κB activity and the regulated gene expression levels, which were derived from NCA. (B) There are six critical genes in our model because their gene expression levels are highly correlated with NF-κB activity. Most of them show sustained (non-decreasing) activity in the period between 4th and 6th hour in the highest dose of stimulus with 1 μg/ml LPS (right column).

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BMC Bioinformatics

ISSN: 1471-2105

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