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Table 4 The confirmation of TRANSPATH® interaction data with the PAAS prediction

From: Functional classification of proteins based on projection of amino acid sequences: application for prediction of protein kinase substrates

Substrate Accession No in UniProt Substrate Name in TRANSPATH® database Kinase type P1-P0 IAP*
O15169 Axin CK1group - 0.637
O15169 Axin GSK3beta 0.844 0.688
O15169 Axin Cdk* 0.031 0.682
P24941 Cdk2 Lyn 0.525 0.722
P17302 Connexin-43 Src 0.754 0.742
P17302 Connexin-43 PKCgroup* 0.863 0.757
P17302 Connexin-43 PKCalpha 0.342 0.643
Q13158 FADD PKCgroup* 0.446 0.757
Q13158 FADD CK1alpha - 0.609
P05230 FGF-1 CK2group - 0.746
P43694 GATA-4 ERK2 0.915 0.697
P43694 GATA-4 GSK3beta 0.688 0.688
Q16665 HIF-1alpha ERK1 0.038 0.632
Q16665 HIF-1alpha ERK2 - 0.697
Q01344 IL-5Ralpha Lyn 0.153 0.722
P17535 JunD ERK2 0.749 0.697
P17535 JunD JNK2 0.686 0.653
P17535 JunD JNK1 0.642 0.766
Q13233 MEKK1 ABL1l 0.044 0.661
Q13233 MEKK1 PKCgroup - 0.757
Q13233 MEKK1 GSKgroup* 0.371 0.616
O15151 Mdm4 CK1alpha 0.183 0.609
O15151 Mdm4 ATM 0.818 0.779
P27361 ERK1 Lck - 0.824
P27361 ERK1 MAPKgroup 0.627 0.824
Q16539 p38alpha p38aplha 0.482 0.737
Q13469 NF-AT1 JNK1 0.301 0.766
Q13469 NF-AT1 CK1group 0.664 0.637
Q13469 NF-AT1 PKCzeta 0.193 0.701
P16234 PDGFRalpha ABL1 0.305 0.661
P09619 PDGFRbeta ABL1 0.468 0.661
P53350 Plk1 Cdk1 - 0.648
P53350 Plk1 PKAgroup - 0.668
P28749 p107 CDKgroup* 0.636 0.682
Q13309 Skp2 Cdk2 0.249 0.761
Q9Y6H5 Synphilin-1 GSK3Beta 0.709 0.688
Q9Y6H5 Synphilin-1 CK2group 0.429 0.746
Q93038 DR3 ERK2 0.617 0.697
P10276 RAR-alpha MAPKgroup* 0.845 0.676
P10276 RAR-alpha PKCgroup - 0.757
P23771 GATA-3 MAPKgroup* 0.536 0.676
P29353 Shc-1 Src 0.881 0.742
P29353 Shc-1 ABL1 0.456 0.661
P29353 Shc-1 JNK1 0.126 0.766
P29353 Shc-1 MAPKgroup 0.028 0.676
P29353 Shc-1 Lyn 0.013 0.722
P29353 Shc-1 RSKgroup - 0.658
P35228 NOS2 ERK1 - 0.632
Q07812 Bax PKBgroup* 0.850 0.655
Q07812 Bax JNK1 0.619 0.766
Q07812 Bax MAPKgroup 0.124 0.676
Q13009 Tiam-1 PKCgroup 0.315 0.757
P05771 PKCgroup PDK-1 0.521 0.957
P05129 PKCgamma PDK-1 0.456 0.957
P28482 ERK2 PDK-1 0.690 0.957
  1. *IAP values were calculated for the kinase type (specificity class) at training procedure.