Table 4 The confirmation of TRANSPATH® interaction data with the PAAS prediction
Substrate Accession No in UniProt | Substrate Name in TRANSPATH® database | Kinase type | P1-P0 | IAP* |
|---|---|---|---|---|
O15169 | Axin | CK1group | - | 0.637 |
O15169 | Axin | GSK3beta | 0.844 | 0.688 |
O15169 | Axin | Cdk* | 0.031 | 0.682 |
P24941 | Cdk2 | Lyn | 0.525 | 0.722 |
P17302 | Connexin-43 | Src | 0.754 | 0.742 |
P17302 | Connexin-43 | PKCgroup* | 0.863 | 0.757 |
P17302 | Connexin-43 | PKCalpha | 0.342 | 0.643 |
Q13158 | FADD | PKCgroup* | 0.446 | 0.757 |
Q13158 | FADD | CK1alpha | - | 0.609 |
P05230 | FGF-1 | CK2group | - | 0.746 |
P43694 | GATA-4 | ERK2 | 0.915 | 0.697 |
P43694 | GATA-4 | GSK3beta | 0.688 | 0.688 |
Q16665 | HIF-1alpha | ERK1 | 0.038 | 0.632 |
Q16665 | HIF-1alpha | ERK2 | - | 0.697 |
Q01344 | IL-5Ralpha | Lyn | 0.153 | 0.722 |
P17535 | JunD | ERK2 | 0.749 | 0.697 |
P17535 | JunD | JNK2 | 0.686 | 0.653 |
P17535 | JunD | JNK1 | 0.642 | 0.766 |
Q13233 | MEKK1 | ABL1l | 0.044 | 0.661 |
Q13233 | MEKK1 | PKCgroup | - | 0.757 |
Q13233 | MEKK1 | GSKgroup* | 0.371 | 0.616 |
O15151 | Mdm4 | CK1alpha | 0.183 | 0.609 |
O15151 | Mdm4 | ATM | 0.818 | 0.779 |
P27361 | ERK1 | Lck | - | 0.824 |
P27361 | ERK1 | MAPKgroup | 0.627 | 0.824 |
Q16539 | p38alpha | p38aplha | 0.482 | 0.737 |
Q13469 | NF-AT1 | JNK1 | 0.301 | 0.766 |
Q13469 | NF-AT1 | CK1group | 0.664 | 0.637 |
Q13469 | NF-AT1 | PKCzeta | 0.193 | 0.701 |
P16234 | PDGFRalpha | ABL1 | 0.305 | 0.661 |
P09619 | PDGFRbeta | ABL1 | 0.468 | 0.661 |
P53350 | Plk1 | Cdk1 | - | 0.648 |
P53350 | Plk1 | PKAgroup | - | 0.668 |
P28749 | p107 | CDKgroup* | 0.636 | 0.682 |
Q13309 | Skp2 | Cdk2 | 0.249 | 0.761 |
Q9Y6H5 | Synphilin-1 | GSK3Beta | 0.709 | 0.688 |
Q9Y6H5 | Synphilin-1 | CK2group | 0.429 | 0.746 |
Q93038 | DR3 | ERK2 | 0.617 | 0.697 |
P10276 | RAR-alpha | MAPKgroup* | 0.845 | 0.676 |
P10276 | RAR-alpha | PKCgroup | - | 0.757 |
P23771 | GATA-3 | MAPKgroup* | 0.536 | 0.676 |
P29353 | Shc-1 | Src | 0.881 | 0.742 |
P29353 | Shc-1 | ABL1 | 0.456 | 0.661 |
P29353 | Shc-1 | JNK1 | 0.126 | 0.766 |
P29353 | Shc-1 | MAPKgroup | 0.028 | 0.676 |
P29353 | Shc-1 | Lyn | 0.013 | 0.722 |
P29353 | Shc-1 | RSKgroup | - | 0.658 |
P35228 | NOS2 | ERK1 | - | 0.632 |
Q07812 | Bax | PKBgroup* | 0.850 | 0.655 |
Q07812 | Bax | JNK1 | 0.619 | 0.766 |
Q07812 | Bax | MAPKgroup | 0.124 | 0.676 |
Q13009 | Tiam-1 | PKCgroup | 0.315 | 0.757 |
P05771 | PKCgroup | PDK-1 | 0.521 | 0.957 |
P05129 | PKCgamma | PDK-1 | 0.456 | 0.957 |
P28482 | ERK2 | PDK-1 | 0.690 | 0.957 |