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Figure 3 | BMC Bioinformatics

Figure 3

From: A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

Figure 3

Delta-delta plot visualization of receptor distances in sequence and substructure space. The delta-delta plot visualizes how target distances differ between sequence-based classification (GSK set, y-axis) and substructure-based classification (x-axis). The average distance towards the other targets is plotted for sequence and substructure space. A few targets are highlighted in the plot to serve as examples. These are marked by a black dot and a label that denotes the gene symbol. Targets that are, on average, more distant from the rest are plotted further away from the origin; targets plotted above the diagonal are more distant in sequence space, while targets plotted below the diagonal are more distant in substructure space. For example, the FSH receptor (FSHR) is positioned relatively far from the origin and above the diagonal. This indicates that this receptor is, in general, more distant from the other receptors, most prominent in sequence space.

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