The relationship between sequence and structure conservation in RNA. (A) Relationship between sequence and structure conservation in RNA shown for the 589 pair-wise structure alignments in the HA-RNA09 dataset. Points are colored proportional to the mean of the negative logarithm of the three p-value cut-offs (-ln(P
), and -ln(P
)). Example pair-wise alignments are highlighted with the letters of their respective panels in Figure 1. (B) Relationship between RMSD and sequence conservation. (C) Relationship between secondary and tertiary structure conservation. (D) Relationship between sequence and secondary structure conservation.