Global Granger Causality algorithm applied on experimental data for global network re-construction. (A) The overall mean clustering coefficient (the probability of neighbours being inter-connected) is an order of magnitude larger than the one of a random network (0.022 instead of 1/768 = 0.0013). But the network is not modular: the mean clustering coefficient with respect to degree is more or less constant. (B) Direct ancestors of RFC1, as well as their own direct ancestors. The causal link from DDX5 to RFC1 is now completely identified: an intermediate protein (SLBP) connects them.