Schematic diagram for predicting the synthetic genetic interaction. The simplest case of a synthetic genetic interaction and non-interaction involving two genes is shown (See low left corner of Fig. 1). The green and purple nodes denote two different genes. The node with cross inside means it is knocked out and vice versa. Here, two single deletions would not result in cell mortality but would result in a "synthetic" lethality phenotype. Hit gene pair means mutations in both of these two genes would result in a "synthetic" lethality phenotype.