Figure 3

Metamotif inference from clustered TRANSFAC motifs. Examples of metamotifs inferred with the metamotif nested sampler algorithm from clustered motifs deposited in the TRANSFAC database [37]. Three metamotif sets (A,B,C) were estimated from input motif sets (D, E and F, respectively). A) Two largely similar patterns (metamotifs 1 and 2) are inferred that correspond to the muscle initiator like motifs, with one distinct pattern (metamotif 3) corresponding to the CATTCC-like motifs (members of the TEA family) also found from the cluster. B) shows that the metamotif nested sampler distinguishes a CAGATG-like (metamotif 1) and CAGCTG-like pattern (metamotif 2) from the motif cluster 3E, and separates an Sn (M00044)-like outlier from the two patterns as metamotif 3. C) Three metamotif patterns inferred from the motif set separate the TAACCCG-like (metamotif 1), TTACCCG (metamotif 2) and TAACCGTTT (metamotif 3) like patterns seen in the motif cluster. Notably metamotif3 contains a shorter CCG-like core instead of the CCCG found in the two other metamotifs.