Figure 4

Subnetwork extraction for sorafenib mode of action study. The largest two resulting subnetworks are shown (blue nodes are down-regulated, red ones up-regulated) Proteins in the orange circles belong to the MAPK pathway, which is known to be affected by sorafenib. The green rectangle depicts the part of the largest subnetwork that belongs to the mTOR pathway, has not previously been reported to be affected by sorafenib. The network on the right hand side shows important strength of the algorithm, i.e. that subnetworks are also reconstructed if the centre node (i.e. the hub) is not detected to be regulated.