Figure 1
From: Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Estimated p53 activity and the 95% confidence intervals based on five training genes (DDB2, PA26, TNFRSF10b, p21 and Bik) that are positively regulated by P53. (A) Estimates from the three replicates of microarray expression data. (B) Estimates from the mean of the three-replicate expression data. (Dash-dot line: p53 activities measured by Western blot [10]. The protein level p53 activation come a time-course immunoblot examination of p53 phosphorylated on S15; dash line: estimate of the HVDM method; solid line: prediction of the nonlinear model.)