Figure 2
From: Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Estimated p53 activity and the 95% confidence intervals based on five training genes (RAD21, CDKN3, PTTG1, MKI67 and IFITM1) that are negatively regulated by P53. (A) Estimates from the three replicates of microarray expression data. (B) Estimates from the mean of the three-replicate expression data. (Dash-dot line: p53 activities measured by Western blot [10]; dash line: estimate of the HVDM method; solid line: prediction of the nonlinear model.)