Figure 4

Expression profiles of four p53 target genes that were identified by the HVDM method. (A) Gene DENND2D (probe ID 221081_S_AT) was also predicted in this work. (B) Gene RRM1 has two probe set ID 201477_S_AT (dash-line, predicted by the HVDM method) and 201476_S_AT (solid-line, not listed in [10]). Probe 201476_S_AT has smaller model error and thus is listed in [Additional file 2]. Probe 201477_S_AT was removed from our prediction. (C) Gene CROT (probe ID 204573_AT) was removed from our consideration because it has no p53 binding motif on its regulatory region. (D) Gene GAL3ST4 (probe ID 219815_AT) was excluded from our consideration because it has relatively larger model estimation error. (Line: simulation of the nonlinear model, star: microarray gene expression profiles.)