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Figure 1 | BMC Bioinformatics

Figure 1

From: Beyond co-localization: inferring spatial interactions between sub-cellular structures from microscopy images

Figure 1

Illustration of co-localization analysis and cellular context. (A) Illustration of co-localization analysis based on nearest neighbor distances (arrows) between point-like objects (dots) and circular objects (solid circles). For all distances d, the state density q(d) is proportional to the total length of the d-isoline (dashed lines) in Ω. The expected co-localization in the absence of interactions, , is proportional to the area enclosed by the t-isoline (gray region). (B)-(D) Effect of the positioning of the objects Y on q(d), illustrating the influence of the cellular context.

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