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Table 1 Illustration of the empirical FWER based on a nominal two-sided 0.05 level, with m= 200 genes, N= 200 simulation samples and B= 200 resampling replications per sample. The outlier law realizes values -4,0 or 4 with probabilities π/2, 1 - π and π/2 respectively. Under simulation model 1, the outlier effect is added to all time-points. Under simulation model 2, the outlier effect is only added to the first and last time-points.

From: Robust test method for time-course microarray experiments

   Simulation 1 Simulation 2
π ρ -PERM -PERM -BOOT -PERM -PERM -BOOT
0 0 0.035 0.060 0.060    
  0.3 0.040 0.035 0.035    
  0.6 0.040 0.040 0.040    
0.05 0 0.040 0.040 0.040 0.065 0.075 0.155
  0.3 0.040 0.055 0.055 0.050 0.065 0.160
  0.6 0.060 0.045 0.055 0.075 0.055 0.130
0.1 0 0.035 0.040 0.050 0.035 0.040 0.355
  0.3 0.040 0.045 0.055 0.050 0.075 0.355
  0.6 0.060 0.045 0.045 0.050 0.055 0.295